Small proteins missing and hormone-neurotransmitter-enzymes decreased in Arsenicosis: Study
Dhaka, Aug 28 (UNB)-A new study has discovered that some small molecular weight proteins are missing and some hormone-neurotransmitter-enzymes decreased in Arsenicosis, a human physiological disorder caused by abnormal accumulation of arsenic in body.
It also found that some large molecular weight proteins are accumulated in human body in Arsenicosis.
Dr M Khalilur Rahman, Professor of Department of Bio-chemistry and Molecular Biology, Dhaka University, detected this in his breakthrough findings.
Arsenic is a natural chemical element widely distributed in biosphere. Arsenic and its compounds are highly toxic.
Dr. Khalil is former Pro-Vice Chancellor of National University and also former VC of Maulana Bhashani Science and Technology University.
In his research, he found that in arsenicosis the neuronal activities decreased as demonstrated by the decrease in the activities of the
Dopamine-beta-hydroxylase (DBH).
AADC(aromatic L-amino acid decarboxylase), DBH, etc, are the enzymes that produce the neurotransmitters-hormones, that is dopamine, norepinephrene(noradrelanine), pinephrine(adrenaline), serotonin which controls emotion, behaviours, sleep, mood, sex and brain and nervous functions of higher animals including the human subjects.
Dr Khalil also found that in arsenicosis high molecular weight proteins are accumulated in the body resulting skin lesion and spotted skin.
On the other hand the low molecular weight proteins which are very important for the productions of neuropeptides, hormones, neurotransmitters and amino acids, are missing in the blood of arsenic affected patients. As a result various physiological disorders took place.
For last few years, Prof Khalil and his associates are carrying out these research works on effects of Aresenicosis on the Serum Proteins and Enzymes levels of patients of Bangladesh.
In the research study serum samples of 12 arsenic affected patients of both male and female aged between 15 to 45 years were taken and analyzed, which shows that protein synthesis is affected in arsenicosis.
The study has found that level of Dopamine-beta-hydroxylase decreased and levels of Aspartate Amino Transferase (AST), elevation of which linked in heart-disease and Alanine Amino Transferese (ALT), elevation of which linked to liver disease, increased in arsenicosis.
Talking to UNB, Prof. Khalil who discovered aromatic L-amino acid decarboxylase (AADC) in mammalian blood for the first time in 1970 at Tokyo Institute of Technology said he wants to carry out further studies to identify the high molecular weight proteins and missing low molecular weight proteins.
Following those findings, the researcher, who had also established several highly sensitive assays for enzymes and drugs in Japan, would further go through more molecular levels to find out their nature and amino acid compositions to the both categories of proteins and also to raise their antibodies.
Prof Khalil will go for identification of genes to find out effective drugs against arsenicosis.
According to surveys and studies more than 35 million people in Bangladesh is exposed to arsenic contamination in drinking water exceeding the national standard of 50 microgram per litre, and an estimated 57 million people are at the risk of exposure to arsenic contamination exceeding the World Health Organization (WHO) guideline of 10 microgram per litre.
Some 220, 000 people have already displaying symptoms of arsenicosis, according to a study in 1997.
Conventionally, hair and nail samples are analyzed for the identification of arsenicosis, because arsenic is not normally found in blood at detectable level unless high dosages are immediately ingested.
The normal level of arsenic in nail is 0.3-1.08 milligram per kilogram. The 12 samples in the research were analyzed arsenic level was found to all the samples 2.5 mg /kg or more.
More than 1.0 mg/kg of arsenic in hair is toxic. All the 12 samples analyzed contained 2.5 mg/kg of arsenic or more. Thus the case of arsenicosis was confirmed.
It also found that some large molecular weight proteins are accumulated in human body in Arsenicosis.
Dr M Khalilur Rahman, Professor of Department of Bio-chemistry and Molecular Biology, Dhaka University, detected this in his breakthrough findings.
Arsenic is a natural chemical element widely distributed in biosphere. Arsenic and its compounds are highly toxic.
Dr. Khalil is former Pro-Vice Chancellor of National University and also former VC of Maulana Bhashani Science and Technology University.
In his research, he found that in arsenicosis the neuronal activities decreased as demonstrated by the decrease in the activities of the
Dopamine-beta-hydroxylase (DBH).
AADC(aromatic L-amino acid decarboxylase), DBH, etc, are the enzymes that produce the neurotransmitters-hormones, that is dopamine, norepinephrene(noradrelanine), pinephrine(adrenaline), serotonin which controls emotion, behaviours, sleep, mood, sex and brain and nervous functions of higher animals including the human subjects.
Dr Khalil also found that in arsenicosis high molecular weight proteins are accumulated in the body resulting skin lesion and spotted skin.
On the other hand the low molecular weight proteins which are very important for the productions of neuropeptides, hormones, neurotransmitters and amino acids, are missing in the blood of arsenic affected patients. As a result various physiological disorders took place.
For last few years, Prof Khalil and his associates are carrying out these research works on effects of Aresenicosis on the Serum Proteins and Enzymes levels of patients of Bangladesh.
In the research study serum samples of 12 arsenic affected patients of both male and female aged between 15 to 45 years were taken and analyzed, which shows that protein synthesis is affected in arsenicosis.
The study has found that level of Dopamine-beta-hydroxylase decreased and levels of Aspartate Amino Transferase (AST), elevation of which linked in heart-disease and Alanine Amino Transferese (ALT), elevation of which linked to liver disease, increased in arsenicosis.
Talking to UNB, Prof. Khalil who discovered aromatic L-amino acid decarboxylase (AADC) in mammalian blood for the first time in 1970 at Tokyo Institute of Technology said he wants to carry out further studies to identify the high molecular weight proteins and missing low molecular weight proteins.
Following those findings, the researcher, who had also established several highly sensitive assays for enzymes and drugs in Japan, would further go through more molecular levels to find out their nature and amino acid compositions to the both categories of proteins and also to raise their antibodies.
Prof Khalil will go for identification of genes to find out effective drugs against arsenicosis.
According to surveys and studies more than 35 million people in Bangladesh is exposed to arsenic contamination in drinking water exceeding the national standard of 50 microgram per litre, and an estimated 57 million people are at the risk of exposure to arsenic contamination exceeding the World Health Organization (WHO) guideline of 10 microgram per litre.
Some 220, 000 people have already displaying symptoms of arsenicosis, according to a study in 1997.
Conventionally, hair and nail samples are analyzed for the identification of arsenicosis, because arsenic is not normally found in blood at detectable level unless high dosages are immediately ingested.
The normal level of arsenic in nail is 0.3-1.08 milligram per kilogram. The 12 samples in the research were analyzed arsenic level was found to all the samples 2.5 mg /kg or more.
More than 1.0 mg/kg of arsenic in hair is toxic. All the 12 samples analyzed contained 2.5 mg/kg of arsenic or more. Thus the case of arsenicosis was confirmed.
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